Desensitization of α7 Nicotinic Receptor Is Governed by Coupling Strength Relative to Gate Tightness
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چکیده
منابع مشابه
Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine.
It is hypothesized that desensitization of neuronal nicotinic acetylcholine receptors (nAChRs) induced by chronic exposure to nicotine initiates upregulation of nAChR number. To test this hypothesis directly, oocytes expressing alpha4beta2 receptors were chronically incubated (24-48 hr) in nicotine, and the resulting changes in specific [3H]nicotine binding to surface receptors on intact oocyte...
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The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery were estimated from the durations and frequencies of clusters of single-channel currents. Diliganded-open AChR desensitize much faster than either unliganded- or diliganded-closed AChR, which indicates that the desensitization rate constant depends on the status of the activation gate rather than the occup...
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Guo X, Lester RA. Regulation of nicotinic acetylcholine receptor desensitization by Ca . J Neurophysiol 97: 93–101, 2007. First published October 18, 2006; doi:10.1152/jn.01047.2005. The relationship between the concentration of intracellular Ca ([Ca ]i) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using th...
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The relationship between the concentration of intracellular Ca2+ ([Ca2+](i)) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using the whole cell patch-clamp techniques in combination with microfluorescent [Ca2+](i) measurements. Recovery from desensitization was assessed with a paired-pulse agonist applicatio...
متن کاملDesensitization of Mouse Nicotinic Acetylcholine Receptor Channels A Two-Gate Mechanism
The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery were estimated from the durations and frequencies of clusters of single-channel currents. Diliganded-open AChR desensitize much faster than either unligandedor diliganded-closed AChR, which indicates that the desensitization rate constant depends on the status of the activation gate rather than the occupan...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.221754